بررسی الگوی مقاومت آنتی‌بیوتیکی سویه های کلبسیلا پنومونیه جداشده از نمونه‌های ادراری در بیمارستان‌های آموزشی دانشگاه علوم پزشکی شهید صدوقی یزد

Abstract Introduction: Klebsiella pneumoniae is an opportunistic pathogen that causes urinary tract Infection (UTI), intra-abdominal infection and pneumonia in patients with weakened immune systems or underlying diseases. Several studies have shown that the indiscriminate and irregular use of antibiotics can cause antibiotic resistance. Antimicrobial resistance has been introduced as one of the most important global health risks by the World Health Organization (WHO). Due to the increasing resistance of pathogens to antibiotics, antibiotic resistance patterns of Klebsiella pneumoniae strains isolated from urine samples have been investigated. Methods: In this descriptive-sectional study, 130 isolates of Klebsiella pneumoniae were collected from hospitalized patients with urinary tract infections and identified by biochemical tests. Antimicrobial susceptibility test was evaluated by standard disk diffusion method (Kirby-Bauer) that has been recommended by the CLSI. Results: From 130 strains of Klebsiella pneumoniae, 72 strains (55.4%) were isolated from female patients. The results showed that the highest rate of resistance was belonged to amoxicillin (100%) and cefotaxime (41.5%) respectively and the lowest rate of resistance was for meropenem (3.8%) and ertapenem (3.8%). Conclusion: The results of this study and other similar studies show that resistance to different antibiotics  have been acquired, so it is recommended that antimicrobial susceptibility tests should be performed before treatment and the results are reported to the clinicians and infection control committees.