بقای بدون بیماری در بیماران سرطان پستان و تعیین عوامل موثر

Background: Mediterean region. Disease-free survival is common to evaluate the treatment of cancers. Severalfactors have been determined as prognostic factors for disease-free survival in studies.Breast cancer is the most common cancer among women especially in easternMethods: in Fayazbakhsh hospital, Tehran. These patients had no metastasis at the time of diagnosis. Patientsunderwent MRM or BCS surgery. All patients followed until 2011 April. Metastases were diagnosedwith x-ray, Biochemical methods, ultrasound with oncologist confirmation. A Cox’s regression withtime to first event variable was used to determine the prognostic factors. Kaplan-Myer method wasused to estimate the survival function. All statistical methods ran in R software version 2.10.In this cross-sectional study, during 2005-2007, 153 women with breast cancer were treatedResults: 99(74.4%) without metastasis and 9 patients(6.8%) experienced a metastasis. Using Kaplan-Myerestimation showed that disease-free survival was 64 months, and five years rate of disease-free was 72percent. Increasing in disease-free survival was associated with low grade of tumor, low number ofinvolved lymph nodes, ER negative and HER2 negative. Odds ratio of metastasis or death for HER2positive was 2.46 times of HER2 negative. Patients with grade 3 had risk of metastasis 1.69-fold ofgrade2.Out of 133 patients, 25(18.8%) died and 108(81.2%) were alive. Out of alive patients,Conclusion: nodes were prognostic factors. Age, size of tumor and PR were not identified as prognostic factors.The result of this study showed that HER2, ER, Grade and number of involved lymph