Association of IL-19 Gene Polymorphism (rs2243191T / C) with occurrence of preeclampsia in pregnant women

Introduction: Preeclampsia, the most common, yet unknown, pregnancy-related disease, is the leading cause of maternal mortality worldwide. Increased systemic inflammatory factors as a result of decreased serum levels of anti-inflammatory cytokines during pregnancy have made inflammation a key role in preeclampsia. In the present study, the relationship between the interleukin 19 polymorphism as an anti-inflammatory cytokine with preeclampsia was investigated. Materials and method: In the present research, case-control study conducted at Islamic Azad University of Kazerun in 2017, 150 preeclampsia patients and 150 healthy pregnant women were enrolled. The rs2243191T/C polymorphism was determined by ARMS-PCR method. Data were analyzed by SPSS software using Chi-square and T-test statistical test. Results: Results showed that there was a significant difference in frequency of CC, CT and TT genotypes (P =0.05) in the position of the rs2243191T/C polymorphism  between preeclampsia pregnant women and healthy pregnant women. There was no significant difference in frequency of both C and T alleles  in this position between the two groups (P = 0.208). Except for the seizure (P =0.003) and age at onset of disease (P =0.015) parameters, for other factors were measured such as urinary protein excretion, patient swelling, hypertension, hypothyroidism, diabetes mellitus, history of miscarriage, previous history of Preeclampsia, multiple pregnancy, primipara and multipara were not significantly different between the case and control groups. Conclusion: Due to the significant association between rs2243191T/C polymorphism and the occurrence of preeclampsia, the presence of this polymorphism can be considered as a predictor of preeclampsia.