Evaluation of Tissue Expression and Salivary Levels of HER2/neu in Patients with Head and Neck Squamous cell Carcinoma

نویسندگان

  • Azadeh Andisheh Tadbir Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Bijan Khademi Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Hooman Ebrahimi Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Marzieh Hamzavi Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mohammad Javad Ashraf Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mohammad Javad Fattahi Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Sara Purshahidi Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Soheil Pardis Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Yasaman Sardari Department of Oral and MaxillofacialPathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده مقاله:

Introduction: HER2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. The purpose of this study was to determine the salivary levels and tissue expression of HER2/neu in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathologic parameters.   Materials and Methods: Enzyme-linked immunosorbent assays (ELISA) were used to evaluate the salivary levels of HER2/neu and immunohistochemistry was used to measure tissue expression of HER2/neu in 28 patients with HNSCC and 25 healthy control subjects.   Results: The salivary levels of HER2/neu in patients with HNSCC were not significantly higher compared to healthy control subjects. There was no apparent correlation between salivary HER2/neu levels and clinicopathological features such as age, sex, tumor grade, tumor size and nodal status. All HNSCC specimens were positive (membranous or/and cytoplasmic) for HER2/neu, except one sample. Only one HNSCC specimen showed staining purely in the tumor-cell cytoplasm. All control specimens were also positive for both membranous and cytoplasmic HER2/neu but there was a significant difference between the level of cytoplasmic staining in the HNSCC specimens and in the control specimens (P

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evaluation of tissue expression and salivary levels of her2/neu in patients with head and neck squamous cell carcinoma

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عنوان ژورنال

دوره 24  شماره 4

صفحات  161- 170

تاریخ انتشار 2012-10-01

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