P-154: Comparison between The Effect of 17-Bestradiol at Preovulatory and Pregnancy Levels for In Vitro Generation of Regulatory T Cells

نویسندگان

  • Idali F
  • Jeddi Tehrani M
  • Mahdavipour M
  • Mirzadegan E
  • Vahedian Z
  • Zarnani AH
چکیده مقاله:

Background: Naturally occurring CD4+CD25+ regulatory T cells (Treg) exert an important role in mediating maternal tolerance to the fetus during pregnancy. During pregnancy the elevated number of regulatory T cells (Tregs) correlates with 17-b oestradiol (E2) level. The role of maternal hormones in successful pregnancy is well known. Maternal hormones through re-engineering of the maternal immune response provide protection for the semi-allogeneic fetus, while any changes in maternal tolerance may lead to abortion, and reproductive abnormality. The aim of this study was to compare the effect of E2 at preovulatory and pregnancy levels for generation of Tregs in vitro. Materials and Methods: We treated the magnetic bead separated peripheral blood na

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عنوان ژورنال

دوره 7  شماره 3

صفحات  95- 95

تاریخ انتشار 2013-09-01

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