P-231: The Effect of Ceftriaxone on Testicular Tissue of Adult Male Mice

Background: Ceftriaxone is an antibiotic used for treating respiratory,skin,bone and kidney infections. Our purpose was investigating effect of ceftriaxone on testicular tissue. Materials and Methods: 40 mice with 6 weeks old were used in this study. The mice randomly were divided into 2 groups, control- sham and test groups. The test group was subdivided to IP1 and IP2 which received Ceftriaxone with 20 mg/kgBW and 50 mg/kgBW dose for 45 days respectively. Testicular weight (TW), tubular diferentiation index (TDI), repopulation index (RI), thickness of testicular capsul (TTC), thickness of interistitial seminiferous tubuls (TIST), seminiferous diameter (SD) and number of leydig cells were evaluated. Results: Histological investigations in test groups revealed a significant reduction in percentage of leydig cells. Light microscopic showed atrophy of seminiferous tubuls. Ratio of spermatogonia B to A (TDI) decreased. TDI positive decreased in test group. Conclusion: these data revealed that ceftriaxone had adverse effect in testicular tissue