Relationship of blood levels of vitamins A and E with psoriasis

Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy persons. Vitamin A and E levels were detected with the use of HPLC method. P value less than 0.05 (P<0.05) was considered as significant.Results: Demographic features were matched between groups. Vitamin A level was 1.09×0.27 in control group and 1.08×0.36 in patient group which did not have a meaningful statistical difference (p=0.91). Vitamin E level was 15.52×8.36 in control group and 9.02×5.41 in patient group and the difference was statistically significant (p=0.001). Comparing vitamin A and E levels according to disease severity showed no statistically significant difference.Conclusion: Our results show that vitamin E level in psoriasis patients is lower than healthy group that were matched by age and gender; although vitamin A level was not different between patient and control groups.