Statistical Study to Find the Optimal Dose of the First Phase in Leukemia Patients
نویسندگان
چکیده مقاله:
Abstract. In this paper, a structured framework for determining the optimal dose of the first phase in leukemia patients is presented. And here we describe and discuss the key parameters that are needed to set up and run a CRM trial. These are: number of doses; maximum tolerable dose; Target Toxicity Level Dose-toxicity model; Dose-toxicity skeleton; Sample size and cohort size and Stopping rules.
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عنوان ژورنال
دوره 31 شماره 2
صفحات 441- 459
تاریخ انتشار 2021-02
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