Synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities
نویسندگان
چکیده مقاله:
The reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded BNPs-3-propyl-imidazolopyridinium hydrogen sulfate [BNPs-Caff]HSO4 as a new BNPs-supported ionic liquid (IL) catalyst. [BNPs-Caff]HSO4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl acetoacetate, barbituric acid, and an aldehyde. The attractive features of this method are simple procedure, clean reaction, use of a reusable catalyst, easy workup, and performing a multi-component reaction (MCR) in water. A number of synthesized compounds were screened for their in vitro anti-bacterial activities against the Gram-positive and Gram-negative bacteria using a well-diffusion method.
منابع مشابه
synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities
the reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded bnps-3-propyl-imidazolopyridinium hydrogen sulfate [bnps-caff]hso4 as a new bnps-supported ionic liquid (il) catalyst. [bnps-caff]hso4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl aceto...
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عنوان ژورنال
دوره 7 شماره 1
صفحات 27- 35
تاریخ انتشار 2017-03-01
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