Synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities

نویسندگان

  • Khosrow Jadidi Department of Chemistry, Shahid Beheshti University, Tehran 1983963113, Iran.
  • Mahdi Mirzaee School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Iran
  • Mohammad Bakherad School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Iran
  • Rahele Doosti School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Iran
چکیده مقاله:

The reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded BNPs-3-propyl-imidazolopyridinium hydrogen sulfate [BNPs-Caff]HSO4 as a new BNPs-supported ionic liquid (IL) catalyst. [BNPs-Caff]HSO4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl acetoacetate, barbituric acid, and an aldehyde. The attractive features of this method are simple procedure, clean reaction, use of a reusable catalyst, easy workup, and performing a multi-component reaction (MCR) in water. A number of synthesized compounds were screened for their in vitro anti-bacterial activities against the Gram-positive and Gram-negative bacteria using a well-diffusion method.

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synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities

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عنوان ژورنال

دوره 7  شماره 1

صفحات  27- 35

تاریخ انتشار 2017-03-01

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