The effect of interval training and consumption of Urtica dioica hydroalcoholic extract on Heat shock protein 70 and Extracellular matrix metalloproteinase inducer in C57 rats with melanoma cancer

Introduction: It has been suggested that targeted therapy of growth and immune factors may lead to more effective inhibition of tumor proliferation and recurrence in melanoma cancer. The aim of this study was to investigate the effect of interval training and consumption of Urtica dioica hydroalcoholic extract on Heat shock protein 70 (HSP70) and Extracellular matrix metalloproteinase inducer (CD147) in C57 rats with melanoma cancer. Method: In this experimental study, 20 C57 rats were randomly divided into four groups include control (cancer), Urtica dioica (cancer), and Urtica dioica - interval training (cancer). Experimental groups received nettle extract of 30 mg daily per kilogram of body weight. The interval exercise program included running on a treadmill 60 minutes at a speed of 28 meters per minute, five days a week for six weeks. The HSP70 and CD147 ranks were measured by Western blotting. The data were analyzed and analyzed by One -way variance analysis and the Toky's test at the p<0.05. Results: The results showed that interval training, Urtica dioica hydroalcoholic extract and interval training with Urtica dioica hydroalcoholic extract consumption led to significant increase in the amount of HSP70 and significant decrease in the amount of CD147 in C57 rats with melanoma cancer (P<0.001). Conclusion: According to the results, it seems that interval training and Urtica dioica hydroalcoholic extract consumption can help regulate growth and immune factors in melanoma cancer.