Up-Regulation of Integrinsn α2β1 and α3β1 Expression in Human Foreskin Fibroblast Cells after In-Vitro Infection with Herpes Simplex Virus Type 1

up-regulation of integrinsn α2β1 and α3β1 expression in human foreskin fibroblast cells after in-vitro infection with herpes simplex virus type 1

the interaction of herpes simplex virus type 1 (hsv-1) with human fetal foreskin fibroblast (hfff) cell was studied using a recent isolate of hsv-1 which was propagated in hep-2 cells. hfff cells were challenged with hsv-1 with a multiplicity of infection (moi) of 1 virus/cell for 24 hours. flow cytometric analysis demonstrated that hsv-1 challenged hfff cells expressed increased levels of α2β1...

Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro

Background: The emergence of drug-resistant strains of herpes simplex virus type 1 (HSV-1) has been increasingly reported. Therefore, attempts to discover new antiviral agents in particular from natural compounds are required. In this study, we evaluated the possible inhibitory effects of hydroalcoholic extract of Sambucus ebulus (S. ebulus) against HSV-1.    Methods: S. ebulus extract was pro...

Prevalence of Herpes Simplex Virus type-1, 2 and Varicella Zoster Virus (VZV) in Eye Infection

Abstract Background and Aims: Herpes simplex virus (HSV) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. This study is aimed to provide an estimation of the incidence of Herpes Simplex Virustype-1, 2(HSV1, 2) and Varicella Zoster Virus (VZV) in tears and swab from eye infection by polymerase chain reaction (PCR) in eye ...

Expression and in vitro Characterization of Herpes Simplex Virus 1 (HSV-1) ORF P Protein

Herpes simplex virus 1 (HSV-1) unspliced 8.3 latency associated transcript (LAT), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (ORF: A-P). One of these ORF, ORF P, maps almost entirely antisense to HSV-1 neurovirulence gene, ICP34.5. Both ORF P and ICP34.5 are located in the long repeat and are antisense overlapping genes. Therefore, in O...

Detection of Herpes Simplex Virus Infection in Cerebrospinal Fluid

ABSTRACT        Background and Objective: Herpes simplex encephalitis is a life-threatening consequence of the central nervous system (CNS) infection with Herpes simplex virus (HSV). Although it is a rare disease, mortality rates reach 70% in the absence of therapy and only a minority of individuals can return to normal function. The aim of this study was to d...

Macromolecular synthesis in cells infected with Herpes simplex virus