Sahar Moghbelinejad
Department of Biochemistry and Genetic, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
[ 1 ] - CRISPR/Cas9, a new approach to successful knockdown of ABCB1/P-glycoprotein and reversal of chemosensitivity in human epithelial ovarian cancer cell line
Objective(s): Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, is a well-known strategy to overcome MDR in cancer. The aim of this study was to investigate the efficiency and ability of CRISPR/Cas9 genome editing technology to knockdown ABCB1 gene expression ...
[ 2 ] - افزایش میزان حیات، تعداد و تحرک اسپرم مردان با اسپرماتوژنزیس طبیعی تحت تأثیر عصاره زعفران پس از پدیده انجماد- ذوب
زمینه: امروزه در استفاده از روشهای کمک باروری شاهد به کار بردن روش انجماد اسپرم به میزان زیادی هستیم از طرفی در مطالعههای مختلف، تأثیر منفی انجماد بر شاخصهای مختلف اسپرم نشان داده شده است. هدف: مطالعه حاضر با هدف تعیین اثر زعفران به عنوان یک ماده آنتیاکسیدان بر شاخصهای مختلف اسپرم مردان با اسپرماتوژنزیس طبیعی پس از پدیده انجماد- ذوب انجام شد. مواد و روشها: این مطالعه مورد- شاهدی در سال 13...
[ 3 ] - Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility
Background The tumor necrosis factor alpha (TNF-α) gene is a cytokine involved in systemic inflammation. Results of the association of its polymorphisms with infertility in men are controversial. Objective The aim of this study was to evaluate the association of -308G/A polymorphism in TNF-α gene with different parameters of semen and sperm in infertile men. Methods Participants were 210 me...
[ 4 ] - Mutation in Aminoacyl Trna Synthetase 1 In Autosomal Recessive Intellectual Disability
Background: Intellectual disability (ID) is one of the most common neurodevelopment disorders that caused by both environment and genetic factors. Also genetic defects have involving for approximately 50% of ID etiology, it is demonstrated that genetics play significant role in ID development. The important risk factor in most country in ID is consanguinity marriage. Iran has high frequency of ...
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