Teng Ruyang
Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao 266100, China
[ 1 ] - Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats
Objective(s): The present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. Materials and Methods: Oxaliplatin (5 mg/kg) or saline was administered to adult male Sprague-Dawley rats. Gabapentin (60 mg/kg, IP) or vehicle was injected daily. Mechanical allodynia was assessed us...