Omid Sabzevari
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
[ 1 ] - Novel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods
The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...
[ 2 ] - Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent
Introduction: A noninvasive method of detecting exposure of phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. The most studied imaging agent for apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecu...
[ 3 ] - Novel and efficient method for solid phase synthesis of urea-containing peptides targeting prostate specific membrane antigen (PSMA) in comparison with current methods
The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...
[ 4 ] - Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent
Introduction: A noninvasive method of detecting exposure of phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of apoptosis related pathologies. The most studied imaging agent for apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecu...
[ 5 ] - بررسی اثرات فراکشنهای مختلف و عصاره‌ی دانه گیاه عدس الملک (Securigera securidaca) بر سطح سرمی گلوکز، فاکتورهای خونی و مورفولوژی کبد در موشهای دیابتی
مقدمه: دانه‌ی گیاه عدس‌الملک (Securigera securidaca) را در طب سنتی ایران به عنوان کاهنده‌ی قند خون تجویز می‌کنند. در این مطالعه، اثر خوراکی عصاره‌ی تام دانه و فراکشنهای آن روی موش سوری و صحرایی دیابتی شده با تزریق صفاقی استرپتوزوسین (200 میلیگرم/کیلوکرم) بررسی شد. مواد و روش‌ها: در بررسی حاد، موشهای سوری، دوزهای مختلف عصاره‌ی تام دانه، فراکشنهای کلروفرمی، متانولی، مخلوط فرکشن‌ها، گلی‌بن‌کلامی...
[ 6 ] - Fluorescent Contrast agent Based on Graphene Quantum Dots Decorated Mesoporous Silica Nanoparticles for Detecting and Sorting Cancer Cells
Background and Objectives: The inability of classic fluorescence-activated cell sorting to single cancer cell sorting is one of the most significant drawbacks of this method. The sorting of cancer cells in microdroplets significantly influences our ability to analyze cancer cell proteins. Material and Methods: We adapted a developed microfluidic device as a 3D in vitro model to sorted MCF-7 c...
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