Jamal Shamsara

[ 1 ] - Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

[ 2 ] - Developing a CoMSIA model for inhibition of COX-2 by resveratrol derivatives

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

[ 3 ] - A THREE DIMENSIONAL HTLV-1 MODEL WITH INTRACELLULAR AND IMMUNE ACTIVATION DELAYS

In this paper, a three dimensional mathematical model for HTLV-1infection with intracellular delay and immune activation delay is investigated.By applying the frequency domain approach, we show that time delays candestabilize the HAM/TSP equilibrium, leading to Hopf bifurcations and sta-ble or unstable periodic oscillations. At the end, numerical simulations areillustrated.