Mario Giorgi

[ 1 ] - A rapid and sensitive HPLC-Fluorescence method for determination of Mirtazapine and its two major metabolites in human plasma

A rapid and sensitive HPLC method has been developed for the quantification of mirtazapine (MRZ), a noradrenergic and specific serotonergic inhibitor antidepressant (NaSSA) and its two major metabolites N-desmethylmirtazapine (NDM) and 8-hydroxymirtazapine (8-OHM) in human plasma. The separation was achieved using Chromolith C18 column and a mobile phase of acetonitrile: phosphate buffer (pH=3,...

[ 2 ] - Effect of oral co-administration of frozen-dried grapefruit juice on pharmacokinetics of tramadol in dogs

Tramadol is a centrally acting analgesic drug extensively metabolized in animal species. Its clinicalresponse is mainly due to the M1 metabolite, poorly produced in dogs. Grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. The aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...

[ 3 ] - A rapid and sensitive HPLC-Fluorescence method for determination of Mirtazapine and its two major metabolites in human plasma

A rapid and sensitive HPLC method has been developed for the quantification of mirtazapine (MRZ), a noradrenergic and specific serotonergic inhibitor antidepressant (NaSSA) and its two major metabolites N-desmethylmirtazapine (NDM) and 8-hydroxymirtazapine (8-OHM) in human plasma. The separation was achieved using Chromolith C18 column and a mobile phase of acetonitrile: phosphate buffer (pH=3,...