Arash Goodarzi
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Preparation of Methotrexate loaded PLGA nanoparticles coated with PVA and Poloxamer188
Objective(s): Nanoparticles offer an attractive platform for drug delivery through a wide variety of the body's physiological barriers. Furthermore, modification of nanoparticle surface with moeites such as Poloxamer188 can enhance their accumulation and localization at disease site. In this work, we investigated the physiochemical effect of a scavenger receptor (SR-BI) interac...
[ 2 ] - بررسی اثرات تکثیری هورمون تیروئیدی T4 بر سلول های گلیوبلاستومای مغزی U87
Background: Considering the effect of thyroid hormone on cancer cells, as well as the development of hormonal therapies for cancer cells. The aim of this study was to investigate the effects of cytotoxic thyroid hormones T4 on proliferation of brain glioblastoma cells (U87) in cell culture. Methods: In this laboratory experimental study, U87 cells were randomly divided into control group and g...
[ 3 ] - In vitro and In vivo Investigation of poly(lactic acid)/hydroxyapatite nanoparticle scaffold containing nandrolone decanoate for the regeneration of critical-sized bone defects
Objective(s): Bone tissue engineering is aimed at the fabrication of bone graft to ameliorate bone defects without using autografts or allografts. Materials and Methods: In the present study, the coprecipitation method was used to prepare hydroxyapatite (HA) nanoparticles containing nandrolone. To do so, 12.5, 25, and 50 mg of nandrolone were loaded into poly(lactic acid) (PLA)/nano-HA, a...