Prachi sharma
Apeejay Stya University, Gurgaon, India
[ 1 ] - Development and evaluation of macrophage targeted multidrug therapy against visceral leishmaniasis
In this study, we fabricated PCL-nanoparticles by encapsulating dual drugs as amphotericin B and doxorubicin via double-emulsion solvent evaporation method also incorporated with ligand-lectin for targeting the infested macrophage cells and prove importance against VL. Different independent processing parameters were assessed systematically to enhance the incorporation of the dual agents with d...
[ 2 ] - PLGA-based macrophage-mediated drug targeting for the treatment of visceral leishmaniasis
The potential of PLGA-nanoparticles as a carrier of amphotericin B and doxorubicin against visceral leishmaniasis was evaluated by macrophage-mediated drug targeting approach. PLGA-nanoparticles were modified by coating them with macrophage-specific ligand-lectin. Prior to in-vitro studies, characterization studies were carried out systematically include particle size, surface morphology, perce...
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