Naderi Tehrani, Monir

[ 1 ] - The effect of chronic caffeine administration on hyperalgesia in a rat neuropathic pain model: role of nitric oxide pathway

Background: Neuropathic pain is a chronic pain caused by damage to the central nervous system and the peripheral. Caffeine is a non-selective antagonist of A1, A2a, receptors of adenosine, which has a protective effect on neuropathic pain in some doses by inhibiting A2a, A2b receptors. Considering that the nitric oxide (NO) levels are apparently effective in the parts of caffeine central effect...