Isaac Chukwunwike Abanum

[ 1 ] - Datumetine Preferentially Upregulates NMDAR Signalling Pathways in Different Brain Regions of Mice

Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα i...