Yoshinori Miyake
Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center Research Insititute.
[ 1 ] - Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies
Objective(s): Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using 11C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical 11C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to...
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