To evaluate the factors affecting post operative stress-related urinary incontinence (POSUI), as well as the treatment and prevention of POSUI. Four hundred and eighty-nine patients were retrospectively reviewed between February 1, 2007 and December 31, 2009 who were with grade 2 or greater uterine and/or vaginal vault prolapse without urinary incontinence. Patients merely with pelvic organ pro...

* Department of Biology, University of California at San Diego, La Jolla, California 92093-0357, USA § Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), Tokyo 113-0021, Japan 2 These authors contributed equally to this work. 3 Present address: Department of Biochemistry, New York University School of Medicin...

BACKGROUND We explored the expression pattern, prognostic potential, and functional role of microRNA-588 (miR-588) in human breast cancer (BC). MATERIAL AND METHODS The expression pattern of miR-588 was assessed by qPCR in BC cell lines and human BC carcinomas. The correlations between miR-588 and BC patients' clinicopathological characteristics, as well as BC patients' overall survival, were s...

MicroRNAs (miRNAs) have been demonstrated to be critical in regulating tumor development and progression. The present study investigated the expression of miR‑588 using reverse transcription‑quantitative polymerase chain reaction analysis in 85 cases of lung squamous cell carcinoma (SCC), and observed the correlation between the expression of miR‑588 with clinical pathologic features. The resul...

BACKGROUND In patients with renal or cardiac failure, renal function may be endangered by elevated plasma concentrations of the vasoconstrictor endothelin-1 (ET-1). To mimic effects of pathologically increased plasma ET-1, we gave intravenous ET-1 in healthy subjects and examined whether simultaneous infusion of the ETA-receptor antagonist VML 588 would prevent the effects of ET-1 on the kidney...

Cancers diagnosed in children younger than 15 are increasing at about one percent per year in the U.S.[1] Cancers are now the second leading cause of death among children (after accidents). An estimated 7800 children in the U.S. were diagnosed with new cancers in 1995.[2] Part of this increase results from better diagnosis and better recording of cases by state and federal agencies, but "taken ...

(1R)-1-benzo [b] thiophen-5-yl-2-[2-(diethylamino) ethoxy] ethan-1-ol hydrochloride (T-588) is a compound for the treatment of neurodegenerative disorders, including Alzheimer's disease and cerebrovascular diseases. T-588 reportedly alleviates learning and memory deficits in animal models of dementia. In the present study, we investigated the effects of T-588 on the induction and decay of long-...

http://adc.bmj.com/content/95/8/588.full.html Updated information and services can be found at: These include: References http://adc.bmj.com/content/95/8/588.full.html#related-urls Article cited in: http://adc.bmj.com/content/95/8/588.full.html#ref-list-1 This article cites 22 articles, 10 of which can be accessed free at: service Email alerting box at the top right corner of the online article...