BACKGROUND cis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects in various tissues, including the liver. The present study investigated the possible protective role of curcumin and α-tocopherol against oxidative stress-induced hepatotoxicity in rats upon cisplatin treatment...

Effects of α-, β-, γ- and δ-tocopherols on the proliferation and invasion of AH109A hepatoma cells and their modes of action were investigated. Four tocopherols inhibited the invasion as well as the proliferation of AH109A cells. Their inhibitory effects were more prominent on the invasion than on the proliferation. At 1 µM, α-tocopherol showed most potent anti-invasive activity without any inf...

To evaluate meat quality of beef with different α-tocopherol tissue levels, 55 feedlot steers were fed a barley-based finisher diet with four vitamin E supplementation levels (0, 350, 700 and 1400 IU DL-α-tocopheryl acetate/animal per day) for 120 days. Although the increase in oxidation levels overtime was much smaller (P < 0.001) in the high-medium and high groups, α-tocopherol tissue levels ...

Severe vitamin E deficiency results in lethal myopathy in animal models. Membrane repair is an important myocyte response to plasma membrane disruption injury as when repair fails, myocytes die and muscular dystrophy ensues. Here we show that supplementation of cultured cells with α-tocopherol, the most common form of vitamin E, promotes plasma membrane repair. Conversely, in the absence of α-t...

BACKGROUND A study of herd-level risk factors for calf mortality in large Swedish dairy herds showed low serum concentrations of α-tocopherol and β-carotene in 1-7 day old calves to be more common in high mortality herds. Therefore, we aimed to investigate if calf mortality risk at herd level is associated with concentrations of α-tocopherol and/or β-carotene at individual level in feed, colost...

Glioblastoma is associated with poor prognosis with a median survival of one year. High doses of ionizing radiation is the only established exogenous risk factor. To explore new potential biological risk factors for glioblastoma, we investigated alterations in metabolite concentrations in pre-diagnosed serum samples from glioblastoma patients diagnosed up to 22 years after sample collection, an...

Fluorine toxicity occurs in different parts of the world. It is caused by increase fluorine level waters, especially due to dissolution volcanic rocks over time. Water with high flüorine content can be taken plant and animal irrigations, foods obtained from plants animals, or it directly drinking water.&#x0D; In this study, effects chitosan (CS) oligosaccharide (COS) on some serum trace mineral...

The effects of lead, copper, cadmium and mercury on the content of chlorophyll, proline, retinol, α-tocopherol and ascorbic acid were investigated in 17-day-old bean seedlings (Phaseolus vulgaris L.) grown in Hoagland solution spiked with various concentrations of Pb, Cu, Cd and Hg. Control and heavy metal-treated plants were grown for 10 days in Hoagland solution. Content of total chlorophyll ...

Phthalates are plastic-derived contaminants that ubiquitous in natural environments and function as pro-oxidants. The extent to which phthalates bioaccumulate wild animals associations with oxidative stress poorly understood. Here, we describe relationships between maternally-derived phthalates, lipid peroxidation (malondialdehyde, MDA) the dietary antioxidant α-tocopherol eggs of European herr...