OBJECTIVE Endometriosis is characterized by the ectopic growth of endometrial tissue. One of the first steps to the spread of endometriosis in the peritoneal cavity is the attachment of endometriotic cells to peritoneal surfaces after they have been released into the peritoneal fluid from pre-existing endometriotic lesions. The increased adhesive and proliferative potential of endometriotic cel...

We continue the study of family algebras introduced by the author. In this paper we describe completely the structure of quantum family algebras for two cases of representations with a simple spectrum. 1. Generalities about family algebras 1.1. Basic definitions. A new class of associative algebras related to simple complex Lie algebras (or root systems) was introduced and studied in [K]. They ...

The α-I domain, found in the α-subunit of the leucocyte integrins such as αMβ2 and αLβ2, switches between the open and closed tertiary conformations, reflecting the highand low-affinity ligand-binding states of the integrin that are required for regulated cell adhesion and migration. In the present study we show, by using point mutations and engineered disulphide bonds, that ligand affinity can...

The inserted (I) domain of αLβ2 integrin (LFA-1) contains the entire binding site of the molecule. It mediates both rolling and firm adhesion of leukocytes at sites of inflammation depending on the activation state of the integrin. The affinity change of the entire integrin can be mimicked by the I domain alone through mutations that affect the conformation of the molecule. High-affinity mutant...

A role of endothelial cells in the survival of CLL cells during extravasation is presently unknown. Herein we show that CLL cells but not normal B cells can receive apoptotic signals through physical contact with TNF-α activated endothelium impairing survival in transendothelial migration (TEM) assays. In addition, the CLL cells of patients having lymphadenopathy (LApos) show a survival advanta...

Abstract. Consider a system of particles performing nearest neighbor random walks on the lattice Z under hard–core interaction. The rate for a jump over a given bond is direction–independent and the inverse of the jump rates are i.i.d. random variables belonging to the domain of attraction of an α– stable law, 0 < α < 1. This exclusion process models conduction in strongly disordered one-dimens...

Deep inelastic electron–nucleon scattering allows for fundamental QCD tests investigating the scaling violations of structure functions in the perturbative regime of large values of Q. The detailed knowledge of the structure functions enables to study various aspects of the dynamics of nonAbelian gauge theory, and is necessary for the future experimental search for the Higgs–boson and new parti...

Myeloperoxidase is a leukocyte component able to generate potent microbicidal substances. A homologous invertebrate blood cell protein, peroxinectin, is not only a peroxidase but also a cell adhesion ligand. We demonstrate in this study that human myeloperoxidase also mediates cell adhesion. Both the human myeloid cell line HL-60, when differentiated by treatment with 12-Otetradecanoyl-phorbol-...