Gem-dihydroperoxides as nearly stable peroxidic derivatives of aldehydes and ketones are known important intermediates in synthesis of anti-malaria drugs. Also, because containing high concentration of peroxidic oxygen, recently, some of these compounds have been used as solid, efficient and powerful oxidants in many oxidation organic reactions. Generally, these compounds are synthesiz...

Several pyrazolo [1, 5-a] pyrimidines derivative were prepared by the condensation of substituted of α, βunsaturated carbonyl compounds (chalcones) with substituted 5-amino pyrazole as an alternative polyethylene glycol (PEG-400) as green reaction medium. The reaction is clean with excellent yield, shorter reaction time. The entire synthesized products were characterized by spectral analysis. F...

Although the oxidation of fatty acids by molds has received only superficial study, it has been found that Penicillium roqueforti forms methyl ketones as products of the oxidation. The distinctive taste and odor of bleu cheese is suggestive of 2-heptanone (Hammer and Bryant, 1937), and this compound, together with other methyl ketones, has been isolated from a ripe cheese and identified (Patton...

Ketones smoothly reacted with NBS in the presence of a catalytic amount of p-toluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and su...

α-Hydroxy ketones are valuable synthons in organic chemistry. Here we show that oxidation of vic-diols to α-hydroxy ketones with H2O2 can be achieved with an in situ prepared catalyst based on manganese salts and pyridine-2-carboxylic acid. Furthermore the same catalyst is effective in alkene epoxidation, and it is shown that alkene oxidation with the MnII catalyst and H2O2 followed by Lewis ac...

A chiral Brønsted acid has been developed from a cationic gold(I) disphosphine complex in the presence of alcoholic solvent and applied to the enantioselective protonation reaction of silyl enol ethers of ketones. Various optically active cyclic ketones were obtained in excellent yields and high enantioselectivities, including cyclic ketones bearing aliphatic substrates at the α-position. Furth...

A direct β-coupling of cyclic ketones with imines has been accomplished via the synergistic combination of photoredox catalysis and organocatalysis. Transient β-enaminyl radicals derived from ketones via enamine and oxidative photoredox catalysis readily combine with persistent α-amino radicals in a highly selective hetero radical-radical coupling. This novel pathway to γ-aminoketones is predic...

2-Amino-substituted ketones react with α-methylene ketones under solvent-free conditions at 90 °C in thepresence of a catalytic amount of zirconium dodecylphosphonate to create the corresponding quinolinesin excellent yields. This procedure recommends numerous advantages such as easy work-up, use of mild,reusable and safe catalyst, short reaction timeand high yields. The new compounds have been...

The tetrahydride complex OsH4{xant(PPr2)2} (1, xant(PPr2)2 = 9,9-dimethyl-4,5bis(diisopropylphosphino)xanthene) activates an ortho-C-H bond of benzophenone and acetophenone to give the osmaisobenzofuran derivatives OsH{κ-C,O-[C6H4C(R)O]}{xant(PPr2)2} (R = Ph (2), CH3 (3)). The reaction of 1 with perdeuterated benzophenone leads to 2 partially protiated. The deuterium distribution in the latter ...

Two different transformations of α-(isochromen-1-yl)ketones catalyzed by NHC Brønsted bases are reported. In the presence of a triazole carbene, α-(isochromen-1-yl)ketones isomerized into β-(2-(aroylmethylene)phenyl)-α,β-unsaturated ketones in 38-88% yields, while the same reaction catalyzed by an imidazole carbene produced 1-aroylnaphthalene derivatives in 90-99% yields. This work not only pro...