Background To evaluate the usefulness of fractionated administration of wortmannin combined with γ-ray irradiation in terms of local tumor response and lung metastatic potential, referring to the response of intratumor quiescent (Q) cells. Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. The tumor-...

Essential oils (EOs) or EOs encapsulated in alginate and alginate-cellulose nanocrystal combined with 1.5 kGy X-ray (0.76 kGy/h) γ-ray (6.37 irradiation were applied on dry fermented sausages (DFS). Microbiological quality was tested terms of the reduction Escherichia coli O157:H7 cocktail, Listeria monocytogenes, molds yeasts, lactic acid bacteria (LAB), total mesophilic (TMF) during storage a...

The effect of kalonji (Nigella sativa) extract (NSE) was studied on dermal excision wound of mice whole body exposed to different doses of γ-radiation. The optimum dose was selected by administering mice with different doses of NSE for five consecutive days before whole-body exposure to 6 Gy γ-radiation and creating a full thickness deep dermal wound of 15 mm diameter on the dorsum of mice afte...

BACKGROUND To evaluate the role of γ-H2AX in peripheral blood lymphocytes (PBLs) as a predictive biomarker of the severity of oral mucositis (OM) in head and neck cancer (HNC) patients with receiving radiotherapy. METHODS In vitro assays for evaluating DNA damage and repair kinetics were performed on blood samples withdrawn from 25 HNC patients undergoing radiotherapy or chemoradiotherapy bef...

PURPOSE Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microgravity (hindlimb unloading; HU), continuous low-dose rate γ-irradiation, or a combination of HU and low-dose rate γ-irradiati...

Poly-γ-glutamic acid (γ-PGA) is a naturally occurring polymer, which due to its biodegradable, non-toxic and non-immunogenic properties has been used successfully in the food, medical and wastewater industries. A major hurdle in bacteriophage application is the inability of phage to persist for extended periods in the environment due to their susceptibility to environmental factors such as temp...

An efficient and green protocol for the synthesis of αaminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nanoalumina sulfuric acid (nano-ASA) under microwave irradiation and solvent-free conditions. The advantages of methods are short reaction times, h...