A variety of novel tetrazole derivatives attached to the β-lactam ring was made utilizing heptanitrile in a reaction with generated azide-β-lactam derivatives, and these compounds were then studied using IR NMR spectroscopy. Biological testing showed that most final good antibacterial antifungal activity, particularly derivative (b3), which shown efficacy on par or even superior reference drugs...

The beta-lactam antibiotics are the most widely used of all the groups of antimicrobials, but beta-lactam resistance is increasingly common among members of the Bacteroides fragilis group. Three major mechanisms are involved in beta-lactam resistance, and they act together in certain instances. In the present study, 2 resistant mutants (238m and 1186m) of Bacteroides thetaiotaomicron, obtained ...

The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of subinhibitory concentrations of antistaphylococcal β-lactam antibiotics by an undefined mechanism. Given the variability in the penicillin-binding protein (PBP)-binding profiles of different β-lactam antibiotics, the purpose of this study was to examine the relative enhance...

The enzymatic ring-opening copolymerization of ε-caprolactone (ε-CL) and β-lactam by using Candida antarctica lipase B (CAL-B) as catalyst was studied. Variation of the feed ratios of 25:75, 50:50, and 75:25 of ε-CL/β-lactam was performed. The products contain poly(ε-CL-co-β-lactam) and the homopolymers of poly(ε-CL) and poly(β-lactam). The structure of the copolymers was determined by MALDI-To...

BACKGROUND Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam allergy following allergy patient evaluation in a predominantly pediatric population. METHODS 306 primary care patients referred between January 2010 and June 2015 were assessed fo...

BACKGROUND Patients with a history of beta-lactam antibiotic allergy are often admitted to the hospital with severe or life-threatening infections requiring beta-lactam antibiotics. Strict avoidance of beta lactams to such patients may prevent them from getting adequate coverage and can lead to an increase in the use of alternative antibiotics, which can predispose to antibiotic resistance. Pas...

BACKGROUND The addition of an aminoglycoside to a beta -lactam therapy regimen has been suggested to have a beneficial effect in delaying or preventing the development of antimicrobial resistance. We studied the effect of aminoglycoside/ beta -lactam combination therapy versus beta-lactam monotherapy on the emergence of resistance. METHODS We performed a meta-analysis of randomized, controlle...

This paper considers a wavelet analogue of the classical Ginzburg-Landau energy, where the Hseminorm is replaced by the Besov seminorm defined via an arbitrary regular wavelet. We prove that functionals of this type converge, in the Γ-sense, to a weighted analogue of the TV functional on characteristic functions of finite-perimeter sets. The Γ-limiting functional is defined explicitly, in terms...

A homogenization problem arising in the gradient theory of fluid-fluid phase transitions is addressed in the vector-valued setting by means of Γ-convergence.