BACKGROUND Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease. OBJECTIVE The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 ...

A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The random-effect model was used. The relative risk (95% confidence interval) of bladder cancer was 0.99 (0.95-1.03) for every 100 IU/day increment in vitamin D from diet plus supplement and 0.95 (0.90-1.00) for every 10 nm...

Tocopherols are plant-derived isoprenoids with potent antioxidant activity, which have been implicated in the tolerance of plants to different stresses. However, tocopherol accumulation and biosynthesis fruit, their potential implication postharvest chilling injury (CI), has scarcely studied. Therefore, this work, we investigated peel mandarin fruit three cultivars contrasting susceptibility CI...

An investigation on fatty acid, triacylglycerol, tocopherol, and xanthophyll contents thermal properties of pecan (Carya illinoinensis) kernel oils from two cultivars was carried out. The main acids were oleic followed by linoleic palmitic acids. predominant triacylglycerols OOL, OOO, OLL (where O stands for oleoyl L linoleoyl). Pecan oil is a rich source tocopherols, mainly γ-tocopherol. Two x...

BACKGROUND Compromised immunity and chronic inflammation are thought to contribute to the development of non-Hodgkin lymphoma (NHL). Because tocopherols protect cells through antioxidant mechanisms, they may play a role in NHL etiology. METHODS This nested case-control study within the Multiethnic Cohort examined the association of prediagnostic serum tocopherols levels measured in 271 NHL ca...

Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of the different forms of tocopherols. Using a naturally occurring...

Tocopherols are a class of four natural compounds that can provide nutrition and function as antioxidant in both plants and animals. Maize kernels have low α-tocopherol content, the compound with the highest vitamin E activity, thus, raising the risk of vitamin E deficiency in human populations relying on maize as their primary vitamin E source. In this study, two insertion/deletions (InDels) w...

Recently, it has been reported that α-tocopherol (α-Toc) is effective for amelioration of liver damage. However, it is unknown whether other vitamin E analogs are effective. In this study, we investigated the effects of γ-tocopherol (γ-Toc) and tocotrienols (T3) in rats with fatty liver. Rats fed a vitamin E-deficient diet for four weeks were divided into eight groups: Control, carbon tetrachlo...

BACKGROUND Tocotrienols has been known to lower serum lipid parameters below 500 mg/d, while increase lipid parameters at higher dose of 750 mg/d. δ-Tocotrienol has a novel inflammatory property of concentration-dependent inhibition and activation. Therefore, inhibition (anti-inflammatory) property of tocotrienols at low doses is useful for cardiovascular disease, whereas, activation (pro-infla...