Driving under the influence of cannabis is an important public safety concern. Drug impaired driving endangers those both inside and outside the driver’s vehicle. Smoking, inhaling or eating cannabis with or without alcohol prior to driving is a common practice and increases the risks of driver impairment, motor vehicle crashes and fatalities. There are also new techniques for administering hig...

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main r...