A systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in the present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, and exiting the cells, respectively. Most of the NPs are found to be enclosed in membrane bounded organelles, which are fairly stable (against rupture) as very few NPs are released into the cy...

به منظور تولید رادیوایزوتوپ تکنسیم-۹۹ حاصل از واپاشی رادیواکتیو مولیبدن-۹۹ و خالص‌­سازی محصول فرایند انحلال اسیدی هدف مینیاتوری، لازم است آلودگی ید گازی در حد قابل قبولی کاهش یابد. این جاذب‌های جامد استفاده می‌شود. یکی بهترین مورد موردنیت حاوی نقره تشکیل شده است. پژوهش روش سنتز مشخصات جاذب بررسی قرار گرفته برای تهیه بلورهای حفره‌دار با اندازه حدود ۱۰ میکرومتر نسبت آلومینیم سیلیکون برابر 2/5 شد ...

OBJECTIVES The objective of this study was to determine the national practice patterns of nurse practitioners (NPs) providing care in long-term care (LTC) facilities, including the number and characteristics of LTC facilities that use NPs for any portion of care to residents, NP activities, and employment arrangements between NPs, physicians, and facilities. DESIGN Mailed survey. PARTICIPAN...

In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high...

The effects of silver (Ag) nanoparticles (NPs) on activated sludge in a biological nitrogen removal (BNR) process were investigated under aerobic and anoxic conditions. We show that nitrification was more vulnerable to Ag NPs exposure than denitrification at the same Ag NPs concentration. In continuous operation of the BNR process, a higher inhibitory effect on nitrification was attributed to a...

Functionalized nanoparticles (NPs) are usually used to enhance cellular penetration for targeted drug delivery that can improve efficacy and reduce side effects. However, it is difficult to exploit intracellular targets for similar delivery applications. Herein we describe the targeted delivery of functionalized NPs by homing in on an intracellular target, histone deacetylases (HDACs). Specific...

We have studied in vitro toxicity of iron oxide nanoparticles (NPs) coated with a thin silica shell (Fe3O4/SiO2 NPs) on A549 and HeLa cells. We compared bare and surface passivated Fe3O4/SiO2 NPs to evaluate the effects of the coating on the particle stability and toxicity. NPs cytotoxicity was investigated by cell viability, membrane integrity, mitochondrial membrane potential (MMP), reactive ...

Natural products (NPs) are superior starting point for the major antimicrobials used in clinical trials (Newman and Cragg, 2012; Butler et al., 2014). Such antimicrobial NPs can be obtained from different microorganisms (Polpass and Jebakumar, 2013) and plants (Atanasov et al., 2015). They can be broadly classified as (i) native NPs, (ii) derivatives of NPs, or (iii) synthetic products based on...

Light-emitting 5,6,11,12-tetraphenylnaphthacene (rubrene) nanoparticles (NPs) prepared by a reprecipitation method were treated hydrothermally. The diameters of hydrothermally treated rubrene NPs were changed from 100 nm to 2 μm, depending on hydrothermal temperature. Photoluminescence (PL) characteristics of rubrene NPs varied with hydrothermal temperatures. Luminescence of pristine rubrene NP...

Purpose Lung cancer (LC) is the leading cause of cancer death worldwide. Evidences suggest that both LC cancer stem cells (CSCs) and cancer cells are supposed to be eliminated to achieve superior treatment effect against LC. Salinomycin could eradiate CSCs in various types of cancers, and gefitinib is a first-line therapy in LC. The purpose of the present study was to develop salinomycin-loaded...