Human cytomegalovirus (HCMV) infection of monocyte-derived macrophages (MDM) results in delayed and nonlytic productive viral growth. During late stages of replication, infectious virus remains cell associated in cytoplasmic vacuoles. In order to understand HCMV survival and persistence in MDM, we examined mechanisms involved in the formation and trafficking of HCMV-containing vacuoles in these...

Motivated by evolving business requirements and novel enterprise applications, we propose and implement the Semantic Master Data Management (SMDM), a semanticslevel enhancement to the existing MDM solutions. The SMDM system publishes relational-based master data as virtual RDF store, and injects instantaneous reasoning capabilities into semantic queries. Two kinds of ontologies are introduced t...

BACKGROUND A history of penicillin allergy in patients is common, but only 10-15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done without first carrying out diagnostic skin testing. This is carried out with the major determinant benzylpenicilloyl (PPL) and the minor determinant mixture (MDM), consisting of peni...

Substance P (SP) is a potent modulator of neuroimmunoregulation. We recently reported that human immune cells express SP and its receptor. We have now investigated the possible role that SP and its receptor plays in HIV infection of human mononuclear phagocytes. SP enhanced HIV replication in human blood-isolated mononuclear phagocytes, whereas the nonpeptide SP antagonist (CP-96,345) potently ...

The Modified Direct Method (MDM) is an iterative mesh smoothing method for smoothing planar and surface meshes, which is developed from the non-iterative smoothing method originated by Balendran [1]. When smooth planar meshes, the performance of the MDM is effectively identical to that of Laplacian smoothing, for triangular and quadrilateral meshes; however, the MDM outperforms Laplacian smooth...

Great strides have been made in the optical interconnect for a mode-division multiplexing (MDM) system. The mode multiplexer/demultiplexer (MUX/DEMUX) is the crucial component for the MDM system. We propose and demonstrate a scheme that is different from the reported multiplexing schemes, mode MUX that tackles dual-path MDM signals simultaneously and avoids mode conflict. The performance is exp...

We introduce highly compact resonant-cavity-enhanced magneto-optical switches for metal-dielectric-metal (MDM) plasmonic waveguides. The field profile of the fundamental mode of a MDM waveguide in which the metal is subject to an externally applied static magnetic field is asymmetric. The static magnetic field induced asymmetry, which enhances or reduces the coupling between the waveguide and a...

Which children go on to develop dyslexia? Since dyslexia has a multifactorial etiology, this question can be restated as: what are the factors that put children at high risk for developing dyslexia? It is argued that a useful theoretical framework to address this question is Pennington's (2006) multiple deficit model (MDM). This model replaces models that attribute dyslexia to a single underlyi...

Lopez MA, Pardo PS, Cox GA, Boriek AM. Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttn) model. Am J Physiol Cell Physiol 295: C1092–C1102, 2008. First published August 27, 2008; doi:10.1152/ajpcell.16.2008.—A complex rearrangement mutation in the mouse titin gene leads to an in-frame 83-amino acid deletion in the N2A region of titin. Autosomal recessiv...