Parthenolide is a major sesquiterpene lactone derived from feverfew (Tanacetum parthenium) with known anti-inflammatory activity. Moreover, the anticancer potential of this compound was suggested. In this study, we determined the effect of parthenolide on proliferation of three human cancer cell lines: human lung carcinoma (A549), human medulloblastoma (TE671), human colon adenocarcinoma (HT-29...

The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium. This isolated compound was identified through spectral analyses by UV, infrared, (1)H and (13)C nuclear magnetic resonance imaging, DEPT (distortionless enhancement by polarization transfe...

BACKGROUND AND THE PURPOSE OF THE STUDY Melatonin has recently been found in several plant tissues. Some reports show that the majority of the herbs containing the high level of melatonin have been used traditionally to treat neurological disorders or diseases associated with the generation of free radicals. Current study was undertaken to screen some medicinal plant species with historical evi...

We investigated whether parthenolide, the principal bioactive component of the herb feverfew (Tanacetum parthenium) induced apoptosis in pre-B acute lymphoblastic leukemia (ALL) lines, including cells carrying the t(4;11)(q21;q23) chromosomal translocation. Parthenolide induced rapid apoptotic cell death distinguished by loss of nuclear DNA, externalization of cell membrane phosphatidylserine, ...

parthenolide is major sesquiterpene lactones present in anthemis haussknechtii boiss. & reut. (feverfew). this compound has many effects on different disease such as migrain and cancer. parthenolide was reported from tanacetum parthenium (l.) sch.bip. but other plants of asteraceae family could contain parthenolide. in this study parthenolide was extracted and identified with two methods, fouri...

INTRODUCTION Guayule (Parthenium argentatum Gray, Asteraceae) is a woody desert shrub (Whitworth and Whitehead 1991) which is under commercial development as a domestic source of hypoallergenic natural rubber (Siler and Cornish 1994; Carey et al. 1995; Cornish 1996, 1998; Cornish et al. 1996, 2001; Schloman et al. 1996; Siler et al. 1996; Cornish and Lytle 1999). To expedite commercialization, ...

1598 Vol 350 • November 29, 1997 35% relative to the first trimester, in contrast to the 16% average decrease in the years 1993–96. During the third trimester of 1997, the number of cases of diarrhoea decreased, yet were still 25% above the figures seen in previous years for the same trimester. In Peru and neighbouring countries affected by El Niño— Chile, Ecuador, and Colombia—we anticipate an...