The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1. The role of the second extracellular loop (ECL2) of CLR in binding CGRP and coupling to Gs was investigated using a combination of mutagenesis and modelling. An alanine scan of residues 271...

 In this paper, we study the application of mixed-integer programming (MIP) to the clusterwise linear regression (CLR) problem with the least sum of absolute deviations, which is a type of CLR problem that has received both theoretical and practical interests in recent years. We formulate the problem with a big-M formulation and investigate related issues, including the integration of outlier ...

In this paper we analyse congestion in TCP over ATM-UBR, in particular the association between the congestion measures at the ATM physical and TCP transport layers. Two new indicators, protocol level congestion association factor (PLCAF) and CLR-PRR correlation coefficient are used. ATM cell loss ratio (CLR) and TCP packet retransmission ratio (PRR) are good measures of congestion at their resp...

This paper presents the compilation of the Scheme programming language to .NET. This platform provides a virtual machine, the Common Language Runtime (CLR), that executes bytecode, the Common Intermediate Language (CIL). Since CIL was designed with language agnosticism in mind, it provides a rich set of language constructs and functionalities. As such, the CLR is the first execution environment...

Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks of daily rifampin (RIF) and streptomycin (STR). Although the results have been highly favorable, administration of STR requires intramuscular injection and carries the risk of side effects, such as hearing loss. Therefore, an all-oral, pot...

Renal clearance (CLR), a major route of elimination for many drugs and drug metabolites, represents the net result of glomerular filtration, active secretion and reabsorption, and passive reabsorption. The aim of this study was to develop quantitative structure-pharmacokinetic relationships (QSPKR) to predict CLR of drugs or drug-like compounds in humans. Human CLR data for 382 compounds were o...

BACKGROUND Clopidogrel low response (CLR) is an independent risk factor of adverse outcomes in patients undergoing percutaneous coronary intervention (PCI), and intensified antiplatelet treatments (IAT) guided by platelet function assays might overcome laboratory CLR. However, whether IAT improves clinical outcomes is controversial. METHODS Relevant trials were identified in PubMed, the Cochr...

To clarify the discrepancy between increasing resistance and conservative clinical effects of macrolides on macrolide-resistant Streptococcus pneumoniae, the authors evaluated the effects of sub-minimum inhibitory concentrations of macrolides on pneumolysin. In vitro, S. pneumoniae was incubated with 1, 2 and 4 microg.mL(-1) of clarithromycin (CLR) and azithromycin (AZM) for 8 h. Western blot a...

The common practice of collapsing inherently continuous or ordinal variables into two categories causes information loss that may potentially weaken power to detect effects of explanatory variables and result in Type II errors in statistical inference. The purpose of this investigation was to illustrate, using a substantive example, the potential increase in power gained from an ordinal instead...