OBJECTIVE We assessed whether the association between dietary saturated fatty acids (SFA) and incident coronary heart disease (CHD) depends on the food source, the carbon chain length of SFA, and the substituting macronutrient. APPROACH AND RESULTS From the Rotterdam Study, 4722 men and women (≥55 years) were included. Baseline (1990-1993) SFA intake was assessed using a validated food freque...

هدف : اول پژوهش حاضر شناسایی مقوله‌ها و مفاهیم تجاری‌سازی دانش جهت ارائه یک الگوی مفهومی است. دوم آن آزمون تجربی تجاری سازی می‌باشد.مواد روش‌ها: با راهبرد ترکیبی از نوع اکتشافی انجام شد. مشارکت‌کنندگان در رؤسا، مدیران گروه استادان دانشگاه، متخصصان مراکز رشد دانشگاهی پارک علم فناوری استان گیلان بودند. برای پژوهش، مرحله کیفی30 نفر استفاده نمونه‌گیری هدفمند کمی، 230 روش تصادفی طبقه‌ای به‌عنوان نمو...

A few studies have shown inconsistent results regarding the association between the visceral fat proportion and colorectal adenomas. We aimed to investigate the association between abdominal fat distribution measured by computed tomography (CT) and colon adenoma.A total of 336 participants underwent physical examination, blood tests, colonoscopy, and abdominal computed tomography at Chung-Ang U...

Sanglifehrin A (SFA) is a cyclophilin-binding immunosuppressant but the immunobiology of action is poorly understood. We and others have reported that SFA inhibits IL-12 production and antigen uptake in dendritic cells (DC) and exhibits lower activity against lymphocytes. Here we show that SFA suppresses DC chemokine production and migration. Gene expression analysis and subsequent protein leve...

Sanglifehrin A (SFA) is a novel immunosuppressive natural product that binds to cyclophilin but is structurally distinct from cyclosporin A (CsA). We have investigated the cellular and molecular mechanisms of the action of SFA in T lymphocytes. We show that SFA inhibits T cell proliferation induced by IL-2 with an IC(50) of 200 nM. Distinct from CsA, which also binds to cyclophilin, SFA does no...

This review reappraises dietary advice to reduce and replace SFA for the prevention of CVD. In the 1970s, SFA accounted for about 18% UK food energy, by 2001 it had fallen to 13% and continues to be above the <11% target. Compared with carbohydrates, C12–C16 SFA raise serum total cholesterol (TC), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) without affecting the TC:HDL-C ratio; other SF...

Oversupply of bulk saturated fatty acids (SFA) induces metabolic disorders and myocardial dysfunction. We investigated whether, without causing metabolic disorders, the uptake of individual dietary SFA species alters lipid profiles and induces myocardial dysfunction. C57BL/6 mice were fed various customized long-chain SFA diets (40% caloric intake from SFA), including a beef tallow (HBD), cocoa...

The Slow Feature Analysis (SFA) unsupervised learning framework extracts features representing the underlying causes of the changes within a temporally coherent high-dimensional raw sensory input signal. We develop the first online version of SFA, via a combination of incremental Principal Components Analysis and Minor Components Analysis. Unlike standard batch-based SFA, online SFA adapts alon...