Treatments for disease in the central nervous system (CNS) are limited because of difficulties agent penetration through blood-brain barrier, achieving optimal dosing, and mitigating off-target effects. The prospect precision medicine CNS treatment suggests an opportunity therapeutic nanotechnology, which offers tunability adaptability to address specific diseases as well targetability when com...

Background. The extracellular matrix of the PNS/CNS is unusual in that it dominated by glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties make essential contributions to functional this tissue. Hyaluronan has a relatively simple structure but its space-filling ensure micro-compartments are maintained brain ultrastructure, ensuring ionic niches gradients for ...

Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional similarity between central nervous system (CNS) and k...

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...

The purpose of this study is to survey cross section changes of the animal brain samples during the tension and compression tests and comparison of the experimental results for three animals: bovine, sheep, and rabbit. A linear elastic theory with considering the necking in tension and barreling in compression has been considered for brain tissue. Bridgman method for tension and cross section u...

We report the synthesis of acyl azolium salts stemming from thiazolylidenes CNS, triazolylidenes CTN, mesoionic carbenes CMIC and generation their corresponding radicals enolates, covering about 60 Breslow-type derivatives. This study highlights role additives in redox behavior these compounds unveils several critical misconceptions radical transformations aldehyde derivatives under N-heterocyc...

It is important to know the accurate trajectory of a free fall object in fluid (such as spacecraft), whose motion might be chaotic many cases. However, it impossible accurately predict its long enough duration by traditional numerical algorithms double precision. In this paper, we give predictions same problem new strategy, namely Clean Numerical Simulation (CNS). Without loss generality, disk ...