OBJECTIVES Naked DNA vaccines can be manufactured simply and are stable at ambient temperature, but require improved delivery technologies to boost immunogenicity. Here we explore in vivo electroporation for multivalent codon-optimized human papillomavirus (HPV) L1 and L2 DNA vaccination. METHODS Balb/c mice were vaccinated three times at two week intervals with a fusion protein comprising L2...

Third language (L3) acquisition differs from first language (L1) and second language (L2) acquisition. There are different views on whether L1 or L2 is of primary influence on L3 acquisition in terms of transfer. This study examines differences in the event-related brain potentials (ERP) response to agreement incongruencies between L1 Spanish speakers and L3 Spanish learners, comparing response...

While the prognosis of gastric cancer (GC) remains poor, PD-1 and PD-L1/L2 are promising prognostic biomarkers. We evaluated PD-1 and PD-L1/L2 expression in tumor cells (TCs) and tumor-infiltrating immune cells (TIICs). We determined the Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) infection status in a GC cohort (n=340), then analyzed the relationship between the expression of PD-1, P...

We shall consider formulas of quantified modal logic. G.Mints described in [1] a reduction of an arbitrary formula F of quantified modal logic to a finite set of such formulas G1, ..., Gm that F is derivable in S4 if and only if G1, ..., Gm is derivable in S4. Moreover, the formula Gi i = 1, 2, ..., m has one of the following forms: ∀(L1 ∨ L2), ∀(L1 ∨ L2 ∨ L3), ∀∃(L1 ∨ L2), ∀(L1 ∨ L2), ∀(L1 ∨ ♦...

This study examines the relationship between both first language (L1) and second language (L2) reading attitudes, and learners' performance in L2 extensive reading. Four reading attitude variables were identified (Comfort, Anxiety, Value, Self-perception), both in L1 and L2, according to learners' responses to a questionnaire. Results of analyses using these four variables are summarised on two...

How does interaction affect categorization, and how might this vary between native and non-native speakers? When people use shared labels to categorize objects, they categorize more similarly to each other. We investigated whether interaction leads non-native speakers to categorize in the same way as native speakers. In six rounds, L1-English and L2-English/L1Mandarin speakers individually cate...

Research suggests that the size of the second language (L2) vowel inventory relative to the native (L1) inventory may affect the discrimination and acquisition of L2 vowels. Models of non-native and L2 vowel perception stipulate that naïve listeners' non-native and L2 perceptual patterns may be predicted by the relationship in vowel inventory size between the L1 and the L2. Specifically, having...

Recent reports suggest that nuclear domain(s) 10 (ND10) is the site of papillomavirus morphogenesis. The viral genome replicates in or close to ND10. In addition, the minor capsid protein, L2, accumulates in these subnuclear structures and recruits the major capsid protein, L1. We have now used cell lines deficient for promyelocytic leukemia (PML) protein, the main structural component of ND10,...

Binding of programmed death-1 (PD-1) with its ligands (PD-L1/2) transmits a co-inhibitory signal in activated T-cells that promotes T-cell exhaustion, leading to tumor immune evasion. The efficacy of antibodies targeting PD-1 and PD-L1 has led to a paradigm shift in lung cancer treatment but the prognostic and predictive value of tumor PD-L1 expression remains controversial. Evaluating PD-1, PD...

شرایط افروزش و اشتعال سوخت‌های گداخت هسته‌ای در حضور ناخالص­‌ها، یکی از موارد مهمی است که طراحی قرص‌های سوخت باید مورد توجه قرار گیرد. این مقاله اثر ناخالصی هسته سنگین طلا بر کلیه فرایندهای احتراق پلاسمای غیرتعادلی دوتریم- تریتیم مدل چهار دمایی آن شکل تابع توزیع انرژی رفتار فوتون‌ها تأثیر می‌گذارد بررسی گرفته است. مطالعه شامل اثرات منفی سوخت، طول زمان تشکیل لکه داغ نتایج محاسبات عددی به­ دست آم...