a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...

BACKGROUND Ethanol (EtOH) exposure in neonate rats during a period comparable to the human third trimester, postnatal days (PD) 4 to 9, leads to persistent deficits in forebrain-dependent cognitive function--modeling the dysfunction seen in individuals diagnosed with fetal alcohol spectrum disorders. EtOH-exposed adult rats are impaired in auditory trace fear conditioning (TFC), a form of Pavlo...

In the title compound C(32)H(31)NO(3), the all-yloxy groups on either side of the piperidin-4-one ring are conformationally disordered. The contribution of major and minor components of the allyloxy group at the 3rd position of the ring are 0.576 (4) and 0.424 (4), respectively, and those at the 5th position are 0.885 (3) and 0.115 (3), respectively. The six-membered piperidin-4-one ring adopts...

Pendidikan Indonesia yang berkembang saat ini adalah paradigma konstruktivis. Merupakan teori belajar menekankan keaktifan siswa untuk mengkonstruksi pengetahuannya. Hal menjadi tantangan bagi pendidik menemukan model pembelajaran membantu secara aktif memperoleh pengetahuan dengan mandiri. Penelitian bertujuan mengkaji apakah learning cycle 5E meningkatkan hasil dan dapat dikatakan layak dalam...

Located on the northern coast of Santa Maria Island (Azores Archipelago, central North Atlantic), Lagoinhas section preserves a carbonate buildup correlated with Marine Isotope Substage (MIS) 5e, warmest interval Last Interglacial. The is formed mainly by crustose coralline algae (CCA) identified as Spongites sp., and some subordinate crusts Lithophyllum sp. Neogoniolithon well cf. Titanoderma ...