Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antio...

PURPOSE In patients with multiple sclerosis (MS), Double Inversion Recovery (DIR) magnetic resonance imaging (MRI) can be used to identify cortical lesions (CL). We sought to evaluate the reliability of CL detection on DIR longitudinally at multiple subsequent time-points applying the MAGNIMs scoring criteria for CLs. METHODS 26 MS patients received a 3T-MRI (Siemens, Skyra) with DIR at 12 ti...

OBJECTIVE To assess, among people with HIV, the association of self-reported antiretroviral treatment (ART) and viral load status with condomless sex with an HIV-serodifferent partner (CLS-D). DESIGN Cross-sectional study of 3258 HIV-diagnosed adults in the United Kingdom, 2011-2012. METHODS CLS-D in the past 3 months and self-reported ART/viral load were ascertained by questionnaire. Clini...

We study the computational complexity ofArrival, a zero-player game on n-vertex switch graphs introduced by Dohrau, Gärtner, Kohler, Matoušek, and Welzl. They showed that the problem of deciding termination of this game is contained in NP ∩ coNP. Karthik C. S. recently introduced a search variant of Arrival and showed that it is in the complexity class PLS. In this work, we significantly improv...

The complexity class CLS was introduced by Daskalakis and Papadimitriou in [9] with the goal of capturing the complexity of some well-known problems in PPAD ∩ PLS that have resisted, in some cases for decades, attempts to put them in polynomial time. No complete problem was known for CLS, and in [9], the problems Contraction, i.e., the problem of finding an approximate fixpoint of a contraction...

This paper describes preliminary results on the application of statistical model-checking to systems described with Stochastic CLS. Stochastic CLS is a formalism based on term rewriting that allows biomolecular systems to be described by taking into account their structure and by allowing very general events to be modelled. Statistical model-checking is an analysis technique that permits proper...

Foreign exchange transactions are subject to a unique type of settlement risk. This risk ultimately stems from the difficulty of coordinating separate settlements in two different currencies. Settlement of foreign exchange transactions through the proposed CLS (“Continuous Linked Settlement”) Bank has been discussed as a potential solution to this problem. This paper describes the CLS proposal ...

Background: Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers the possibility of cure for hematological malignancies, various complications have been described. Capillary leak syndrome (CLS) has been previously observed in HSCT patients. CLS is a rare disease characterized by recurrent episodes of generalized edema and severe hypotension along with hypoproteinemia. ...

BACKGROUND Yeast viability and vitality are essential for different industrial processes where the yeast Saccharomyces cerevisiae is used as a biotechnological tool. Therefore, the decline of yeast biological functions during aging may compromise their successful biotechnological use. Life span is controlled by a variety of molecular mechanisms, many of which are connected to stress tolerance a...

Cercospora leaf spot (CLS) is one of the most serious diseases of sugar beet worldwide, and if uncontrolled, causes nearly complete defoliation and loss of revenue for beet growers. The beet sugar industry continuously seeks CLS-resistant sugar beet cultivars as one strategy to combat this disease. Normally human experts manually observe and rate the resistance of a large variety of sugar beet ...