BACKGROUND HIV infected children are at increased risk of TB disease and require annual TB screening. Data on use of IGRA for TB screening in them are limited. We retrospectively evaluated the usefulness of Quantiferon Gold-in-tube test (QFT), an IGRA in screening for LTBI in relatively healthy, immunologically stable HIV infected children. METHODS HIV infected children with no prior history ...

In QFT, quantum mechanical interactions between particles are described by interaction terms between the corresponding underlying fields. QFT interaction terms are similar in spirit to those between charges with electric and magnetic fields in Maxwell's equations. However, unlike the classical fields of Maxwell's theory, fields in QFT generally exist in quantum superpositions of states and are ...

BACKGROUND Although North American hospitals are switching from tuberculin testing (TST) to interferon-gamma release assays (IGRAs), data are limited on the association between occupational exposure and serial QuantiFERON-TB Gold In-Tube (QFT) results in healthcare workers (HCWs). METHODS In a cohort of Canadian HCWs, TST and QFT were performed at study enrolment (TST1 and QFT1) and 1 year la...

BACKGROUND Clinical roles of QuantiFERON-TB Gold (QFT-G)/Gold in-Tube (QFT-G-IT) and T-SPOT.TB in tuberculosis require clarification. METHODS MEDLINE and EMBASE were searched for relevant English papers. Summary estimates of likelihood ratios (LR) of QFT-G/QFT-G-IT and T-SPOT.TB for latent tuberculosis infection (LTBI) and tuberculosis disease in adults were obtained by bivariate and univaria...

A number of elegant approaches have been developed for the identification of quantum circuits which can be efficiently simulated on a classical computer. Recently, these methods have been employed to demonstrate the classical simulability of the quantum Fourier transform (QFT). Here we show that one can demonstrate a number of simulability results for QFT circuits in a straightforward manner us...

BACKGROUND HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold in-tube (QFT-GIT) and Tuberculin skin testing (TST) that convert to QFT-GIT positive following TST, and (2) evaluate the relationship between conversion and baseline QFT-GIT res...

BACKGROUND The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is currently based on the immunological response of T-cells to M. tuberculosis (MTB) antigens. However, the QuantiFERON®-TB Gold In-Tube assay (QFT) has not yet been evaluated in the Thai adult population. OBJECTIVE To evaluate the diagnostic performance and determine predictors of discordant results between the QF...

We review the quaternionic Fourier transform (QFT). Using the properties of the QFT we establish an uncertainty principle for the right-sided QFT. This uncertainty principle prescribes a lower bound on the product of the effective widths of quaternion-valued signals in the spatial and frequency domains. It is shown that only a Gaussian quaternion signal minimizes the uncertainty.

SETTING AND OBJECTIVE To investigate the sensitivity of the new interferon-gamma release assay (IGRA), QuantiFERON®-TB Gold Plus (QFT-Plus), for active TB (used as a surrogate for latent tuberculous infection) in a Zambian TB clinic. DESIGN Consecutive smear or Xpert® MTB/RIF-positive adult (age 18 years) pulmonary TB patients were recruited between June 2015 and March 2016. Venous blood was...

The aim of the present study was to perform cost-minimisation analysis of contact investigation from a public health perspective using the tuberculin skin test (TST) and a new blood assay, QuantiFERON-TB Gold (QFT-G). A decision-analysis model simulated the costs of investigating a cohort of adult close tuberculosis contacts by the public health service following the current German guidelines o...