Objectives: Contemporary data are lacking with respect to the incidence rates of, factors associated with, and impact of cardiac arrest from ventricular fibrillation or tachycardia (VF-CA) on hospital survival in patients admitted with an acute coronary syndrome (ACS). The objectives of this multinational study were to characterize trends in the magnitude of in-hospital VF-CA complicating an AC...

PURPOSE To assess the clinical validity of visual field (VF) archetypal analysis, a previously developed machine learning method for decomposing any Humphrey VF (24-2) into a weighted sum of clinically recognizable VF loss patterns. MATERIALS AND METHODS For each of 16 previously identified VF loss patterns ("archetypes," denoted AT1 through AT16), we screened 30,995 reliable VFs to select 10...

BACKGROUND The combined effects of excitability and action potential duration (APD) restitution on wavefront dynamics remain unclear. METHODS AND RESULTS We used optical mapping techniques to study Langendorff-perfused rabbit hearts. In protocol IA (n=10), D600 at increasing concentrations was infused during ventricular fibrillation (VF). With concentration increased to 0.5 mg/L, fast VF (dom...

Background—Current resuscitation guidelines (2005 guidelines [G2005]) accelerate ventricular fibrillation (VF) recurrence. We investigated whether patients resuscitated under G2005 spend more time in VF and have better survival rates than patients treated under the 2000 guidelines (G2000). Methods and Results—We analyzed continuous ECG recordings of out-of-hospital cardiac arrests prospectively...

In patients with Brugada syndrome (BS), VF occurred predominantly during the nocturnal period. Some patients also developed ESs. In addition to the circadian rhythm, patients showed weekly and seasonal patterns. The patients with ESs had peak episodes of VF on Saturday and in the winter and spring, while episodes of VF in patients with single VF events occurred most often on Monday with smaller...

Using two methods of determining the onset of rebreathing, we have determined the minimum fresh gas flow rate (VF) of the Ohmeda enclosed afferent reservoir breathing system (EAR) in anaesthetized, spontaneously breathing adults. Rebreathing as defined by the Kain and Nunn criteria did not occur when the VF/VE ratio was greater than 0.70. A mathematical model was used to calculate the degree of...

Purpose To compare optic nerve head (ONH) measurements in glaucomatous eyes with paracentral visual field (VF) loss to eyes with peripheral VF loss and controls. Methods Open-angle glaucoma (OAG) patients with early paracentral VF loss or isolated peripheral VF loss as well as control subjects underwent ONH imaging with swept-source optical coherence tomography (OCT) and retinal nerve fiber l...

BACKGROUND Ventricular fibrillation (VF) is maintained by 2 mechanisms: first by reentry formation and second by spontaneous wave break or wave splitting. We hypothesized that spontaneous wave break results from a critical shortening of the action potential duration (APD) during VF and that its prevention by procainamide eliminates spontaneous wave break. METHODS AND RESULTS The endocardial s...

AIMS An early repolarization (ER) pattern is a risk factor for ventricular fibrillation (VF) in certain diseases. However, it is unclear whether this association holds for patients with vasospastic angina (VSA). Moreover, the reported long-term follow-up of implantable cardioverter defibrillator (ICD) therapy for VSA patients is limited to 3 years. This study aimed to clarify the relation betwe...

PURPOSE To determine which version of the Visual Function Index-14 (VF-14) most precisely measured cataract surgery outcomes, rescale the VF-14 using Rasch analysis, and create a short-form version for comparison. SETTING Flinders Medical Centre, Adelaide, South Australia, Australia. METHODS In this cohort study incorporating questionnaire development, participants were drawn from the catar...