The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF...

Composite electrodes were prepared by adding 40 wt % La0.8Sr0.2FeO3 (LSF) into porous yttria-stabilized zirconia (YSZ) and their performance was studied as a function of time and calcination temperature. X-ray diffraction (XRD) patterns of the LSF-YSZ composites indicated an expanded lattice parameter after calcination above 1523 K, suggesting that Zr reacted with the LSF to form a Zr-doped per...

We present a preliminary analysis of the line spread function (LSF) of the Cosmic Origins Spectrograph (COS) using FUV and NUV stellar spectra acquired during the SM4 Servicing Mission Observatory Verification (SMOV). Our results indicate that the on-orbit shape of the COS LSF with the HST optical telescope assembly (OTA) deviates from the profile measured in ground testing due to the appearanc...

L-sulforaphane (LSF) is a natural isothiocyanate found in cruciferous vegetables particularly broccoli. LSF has been identified as a potent antioxidant and anti-cancer agent and is widely known to regulate phase II detoxifying enzymes and induce cell cycle arrest or apoptosis in malignant cells in vitro and in vivo. Previous studies have found significant G2/M cell cycle arrest in response to L...

Lightweight steel-framed (LSF) construction, given its advantages, has the potential to reach high standards in energy and environmental performance of buildings, such as nearly zero-energy buildings (nZEB). When compared with traditional construction, LSF system offers distinct benefits in such fields as sustainability, cost-effectiveness, constructive process, and safety at work. Despite the ...

French Sign Language (LSF) automatic processing research has to deal with uncomplete corpora of a language which is not yet fully described and has no written form. So, the researchers must carry out reductions at every representational level, constrain the conditions of acquisition of LSF discourses and limit the field of their applications. It is important that they should explain and justify...

The current paper proposes skew Gaussian mixture models for speaker recognition and an associated algorithm for its training from experimental data. Speaker identification experiments were conducted, in which speakers were modeled using the familiar Gaussian mixture models (GMM), and the new skewGMM. Each model type was evaluated using two sets of feature vectors, the mel-frequency cepstral coe...

In this paper, we discuss the theoretical, sociolinguistic, methodological and technical objectives and issues of the French Creagest Project (2007-2012) in setting up, documenting and annotating a large corpus of adult and child French Sign Language (LSF) and of natural gestural language. In section 2., we address theoretical and practical issues, emphasizing the outstanding features of the Cr...