BACKGROUND Change in high-density lipoprotein cholesterol (HDL-C) observed in large randomized controlled trials using fibrates has varied. Inconsistent cardiovascular outcomes have also been the common theme of these trials. Subgroup analysis of even the negative trials, however, reveals significant reduction in cardiovascular disease in patients with low HDL-C and high triglycerides. We wishe...

BACKGROUND Insulin resistance (IR) reduces reactivity of the target organ to blood insulin. Researchers have attempted to evaluate IR using various serum lipid concentration ratios. We aimed to determine the most strongly IR-predictive lipid profile ratios for each sex by studying associations between lipid concentration ratios and IR using data from the fifth Korea National Health and Nutritio...

Cardiovascular and other blood related diseases are fast replacing communicable diseases; therefore there is need to constantly monitor our specific deleterious parameters and their associates. In this work, blood samples were collected to determine biochemical parameters: total cholesterol (TC), high density lipoproteincholesterol (HDL C), low density lipoproteincholesterol (LDL-C), very low d...

AIM To explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population. We also provide the clinical utility of lipid ratios to identify men and women with IR. METHODS This cross-sectional study included 614 men and 1055 women without diabetes. Insulin resistance was defined by homeostatic model assessment of IR > 2.69. Lipid ratios included ...

OBJECTIVE The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD) and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS Smooth muscle cells isolated from human aortas cultured and radiolabeled with H-cholesterol were l...

Response to Simvastatin Therapy in Scandinavian Simvastatin Survival Study (4S) To the Editor: Ballantyne et al1 compared the coronary heart disease (CHD) event rate and the response to simvastatin therapy in a subgroup of approximately 500 individuals from the Scandinavian Simvastatin Survival Study (4S) study with “isolated increased LDL-C” with a similarly-sized subgroup that had not only an...

Cardiometabolic risk factors at a young age pose significant for developing atherosclerotic cardiovascular disease in adulthood. Atherogenic dyslipidemia is highly associated with obesity and metabolic syndrome already age. It remains unclear whether cardiometabolic associate the atherogenic index of plasma (AIP = log (TAG/HDL-C) lean subjects low risk. As both AIP markers are continuous variab...

OBJECTIVE To analyze the impact of the substitution of a rich diet in saturated fats with a rich diet in monounsaturated fats on anthropometric, metabolic and lipid profile in postmenopausal women. MATERIAL AND METHODS A prospective, longitudinal and comparative study where 18 postmenopausal women participated in two periods of dietary intervention of 28 days each one: 1) (SAT diet) consumed ...

OBJECTIVE Given the discrepant findings of progressive resistance training (PRT) on lipids and lipoproteins in adults, we used the meta-analytic approach to examine this issue. METHODS Randomized controlled trials > or =4 weeks dealing with the effects of PRT on lipids and lipoproteins in adult humans > or =18 years of age and published between January 1, 1955 and July 12, 2007 were included....