Baratta, Michael V., Tyra Lamp, and Melanie K. Tallent. Somatostatin depresses long-term potentiation and Ca signaling in mouse dentate gyrus. J Neurophysiol 88: 3078–3086, 2002; 10.1152/jn.00398.2002. The selective loss of somatostatin (SST)-containing interneurons from the hilus of the dentate gyrus is a hallmark of epileptic hippocampus. The functional consequence of this loss, including its...

The clinical effectiveness of the Kampo medicine Sho-seiryu-to (SST) has recently been demonstrated in a double-blind randomized study of allergic asthma and rhinitis. We investigated the effect of SST on a type 1 allergic model in mice. Ovalbumin (OVA)-induced sneezing and the total and OVA-specific IgE levels were significantly suppressed with SST at 1.0 g/kg, but that of OVA-specific IgG(2a)...

In part 1 of our review on somatostatin (SST) receptor biology in neuroendocrine tumours, the somatostatin receptor (SSTR) as a G-protein coupled receptor (GPCR), and the anti-tumour effects of SST and SSTR post-signalling pathways, were reviewed. To recapitulate, SST is a peptide hormone which acts mainly as an inhibitor in many endocrine systems. SST has five receptor subtypes (SSTR1–5) with ...

Oviductal sperm storage tubules (SST), located at the uterovaginal junction, are the primary site of sperm storage in turkeys. Sperm reside within these storage sites and may be released via a dynamic interaction between sperm mobility and a fluid current generated by the SST epithelial cells. In this study, aquaporins 2, 3, and 9 (proteins that form water channels in the plasmalemma of a varie...

Purpose. In the mouse model of oxygen-induced retinopathy (OIR), somatostatin-14 (SRIF) acting at the SRIF receptor subtype 2 (sst(2)) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor. Information about where SRIF-sst(2) interactions take place is lacking, and downstream effectors mediating SRIF-sst(2) antiangiogenic actions are unknown. Me...

Locally produced growth hormone (GH) and IGF-I are key factors in the regulation of mammary gland (MG) development and may be important in breast cancer development/progression. Somatostatin (SST) and cortistatin (CORT) regulate GH/IGF-I axis at various levels, but their role in regulating GH/IGF-I in MGs remains unknown. Since obesity alters the expression of these systems in different tissues...

In recent years, the synchrosqueezing transform (SST) has gained popularity as a method for the analysis of signals that can be broken down into multiple components determined by instantaneous amplitudes and phases. One such version of SST, based on the short-time Fourier transform (STFT), enables the sharpening of instantaneous frequency (IF) information derived from the STFT, as well as the s...

Steady State Tokamak (SST-1) refurbishment at the Institute for Plasma Research has been recognized and accepted as a Mission activity since Jan 2009 with an ultimate objective of producing the first plasma by the end of 2011. Under the SST-1 Mission mandate, several refurbishment activities have been initiated and pursued vigorously on various sub-systems of SST-1. Developing reliable designs ...

Recent Lagrangian analyses of surface drifters have questioned the existence of a surface current connecting the Gulf Stream (GS) to the subpolar gyre (SPG) and have cast doubt on the mechanism underlying an apparent pathway for sea-surface temperature (SST) anomalies between the two regions. Here we use modelled Lagrangian trajectories to determine the fate of surface GS water and satellite SS...