BACKGROUND AND OBJECTIVES Cigarette smoking is a risk significant factor in coronary artery disease (CAD) and vasospastic angina (VSA). However, it is largely unknown whether smoking adds to any long-term clinical risk in VSA patients. SUBJECTS AND METHODS A total of 2797 patients without significant CAD underwent acetylcholine (Ach) provocation test between November 2004 and October 2010. Pa...

This study represents a prospective audit comparing carotid artery stenting (CAS) with carotid endarterectomy (CEA), performed by a single surgical team. Between January 2005 and December 2008, 440 patients were referred; 177 had CAS and 263 CEA. Selection of procedure was individualised and contra-indications for CAS included internal carotid artery (ICA) stenosis > 85-90%, intraluminal thromb...

BACKGROUND Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on the occurrence of peri-CAS cerebral ischemic lesions on diffusion-weighted imaging (DWI) scanning. METHODS Coronar...

CSE1L/CAS, a microtubule-associated, cellular apoptosis susceptibility protein, is highly expressed in various cancers. Microtubules are the target of paclitaxel-induced apoptosis. We studied the effects of increased or reduced CAS expression on cancer cell apoptosis induced by chemotherapeutic drugs including paclitaxel. Our results showed that CAS overexpression enhanced apoptosis induced by ...

BACKGROUND Carotid artery stenting (CAS) and carotid endarterectomy (CEA) are alternative strategies for stroke prevention in patients with atherosclerotic carotid disease. Although randomized clinical trials are the gold standard for assessing the relative benefits of different treatments, observational research is necessary for determining "real-world" effectiveness. Current recommendations l...

The aim of this study was to compare the clinical outcomes of early versus delayed carotid artery stenting (CAS) for symptomatic cerebral watershed infarction (sCWI) patients due to stenosis of the proximal internal carotid artery. We retrospectively collected clinical data of those who underwent early or delayed CAS from March 2011 to April 2014. The time of early CAS and delayed CAS was withi...

The age-related imbalance between the increased bone resorption and decreased formation results in the bone loss and osteoporosis. Recently, as the functional role of the seven transmembrane spanning extracellular calcium sensing receptor (CaS) in bone cells has been discovered, the possibility that the bone CaS could potentially be targeted by antagonists to control the bone remodeling has bee...

THÈSE dirigée par : M. Yan CHEN Professeur, ISTO, Université d’Orléans-CNRS, France M. Qingchen WANG Professeur, IGG, CAS, Chine RAPPORTEURS : M. Marc JOLIVET CR, CNRS, Géosciences Rennes, France M. Bihong FU Professeur, KLEDI, CAS, Chine JURY : M. Rixiang ZHU Professeur, IGG, CAS, Chine, Président de Jury M. Romain AUGIER MCF, ISTO, Université d’Orléans-CNRS, France M. Bihong FU Professeur, KL...

The previously proposed cunning ant system (cAS), a variant of the ACO algorithm, worked well on the TSP and the results showed that the cAS could be one of the most promising ACO algorithms. In this paper, we apply cAS to solving QAP. We focus our main attention on the effects of applying local search and parallelization of the cAS. Results show promising performance of cAS on QAP.

Determination of vitamin B12 in all forms of infant, adult, and/ or pediatric formula (powders, ready-to-feed liquids, and liquid concentrates). For the purpose of this SMPR, vitamin B12 is defined as cobalt-containing corrinoids with the biological activity of cyanocobalamin such as cyanocobalamin (CAS 68-19-9), aquocobalamin (CAS 13422-52-1), hydroxycobalamin (CAS 13422-51-0), methylcobalamin...