Continued on page 10 BACKGROUND INFORMATION Pelvic organ prolapse (POP) is uncommon in young women. Most of the 400,000 procedures performed annually in the United States for POP correction are done in perior postmenopausal women (1). Traditionally, most cases of POP are thought to be secondary to damage to the pelvic floor tissues during childbirth and the resulting changes with aging and time...

An Al(porphyrin) functionalized with a large axial ligand was incorporated into a porous organic polymer (POP) using a cobalt-catalyzed acetylene trimerization strategy. Removal of the axial ligand afforded a microporous POP that is catalytically active in the methanolysis of a nerve agent simulant. Supercritical CO2 processing of the POP dramatically increased the pore size and volume, allowin...

-Catenins are conserved regulators of metazoan development that function with TCF DNA-binding proteins to activate transcription. In Caenorhabditis elegans, SYS-1/ -catenin and POP-1/TCF regulate several asymmetric divisions, including that of the somatic gonadal precursor cell (SGP). In the distal but not the proximal SGP daughter, SYS-1/ -catenin and POP-1/TCF transcriptionally activate ceh-2...

BACKGROUND Pelvic organ prolapse (POP) is a common gynecological condition that can affect quality of life (QOL) in women. In Nepal, the prevalence of POP is high, but many affected women are still deprived of treatment. Vaginal hysterectomy with pelvic floor repair is one of the common treatment options for advanced POP. However, QOL outcomes after surgery have not been reported in low-income ...

Pelvic organ prolapse (POP) remains a great therapeutic challenge with no optimal treatment available. Tissue maintenance and remodelling are performed by fibroblasts, therefore altered cellular functionality may influence tissue quality. In this study, we evaluated functional characteristics of fibroblastic cells from tissues involved in POP. To rule out normal ageing tissue degeneration, biop...

The Wnt signaling pathway plays a conserved role during animal development in transcriptional regulation of distinct targets in different developmental contexts but it remains unclear whether quantitative differences in the nuclear localization of effector proteins TCF and β-catenin contribute to context-specific regulation. We investigated this question in Caenorhabditis elegans embryos by qua...

We examine the significance of the first metal-free stars (Pop III) for the cosmological reionization of H I and He II. These stars have unusually hard spectra, with the integrated ionizing photon rates from a Pop III stellar cluster for H I and He II being 1.6 and 10 times stronger respectively than those from a Pop II cluster. For the currently favored cosmology, we find that Pop III stars al...

The priming of popout (PoP) (Maljkovic & Nakayama, 1994, 1996) increases the speed of attentional deployment to subsequent targets having the same feature characteristic and relative position, it lasts for approximately 5–8 trials, and is cumulative. Here we establish PoP as an example of short-term implicit memory by showing that it is qualitatively different from explicit memory. Using a post...

Pelvic organ prolapse (POP) is a common gynecological disorder; however, the genetic components remain largely unidentified. Exome sequencing has been widely used to identify pathogenic gene mutations of several diseases because of its high chromosomal coverage and accuracy. In this study, we performed whole exome sequencing (WES), for the first time, on 8 peripheral blood DNA samples from repr...

Java has become the most important language in the Internet area, but its execution performance is severely limited by the true data dependency inherited from the stack architecture defined by the Sun’s Java Virtual Machine (JVM). To enhance the performance of the JVM, a stack operations folding mechanism for the picoJava-II processor was proposed by Sun Microsystems to fold 42.3% stack push/po...