INTRODUCTION Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker. METHODS Seventy-six obese subjects were randomly placed in...

OBJECTIVE To compare the pathophysiology of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in a more comprehensive and standardized fashion than has hitherto been done. RESEARCH DESIGN AND METHODS We studied 21 individuals with isolated IFG (IFG/normal glucose tolerance [NGT]), 61 individuals with isolated IGT (normal fasting glucose [NFG]/IGT), and 240 healthy control su...

Science is still searching for readily available, cost-effective biomarkers to assess metabolic disorders occurring before the onset and during development of type-2 diabetes (T2DM). The aim present study was induce T2DM in rats through a high-fat diet, followed by single administration low dose streptozotocin (STZ), make an assessment disease. were divided into two groups—experimental control—...

OBJECTIVES The goal was to clarify if insulin resistance (IR) would predict cardiovascular disease (CVD) independent of the metabolic syndrome (MetSyn). BACKGROUND Although the cause of MetSyn is not well defined, IR has been proposed to be an important cause. Only a small number of population-based studies have sought to clarify if IR predicts CVD independent of MetSyn. METHODS This was a ...

BACKGROUND The prevalence of diabetes mellitus is higher in individuals with Down syndrome (DS) than in the general population; it may be due to the high prevalence of obesity presented by many of them. The aim of this study was to evaluate the insulin resistance (IR) using the HOMA (Homeostasis Model Assessment) method, in DS adolescents, describing it according to the sex, body mass index (BM...

The point-counterpoint articles in the September issue of Diabetes Care (1,2) raise several interesting issues on our understanding of insulin resistance, homeostasis model assessment (HOMA), and the future of measurement shortcuts for insulin resistance and secretion. McAuley et al. (1) provide an overview of methods to assess insulin sensitivity and secretion. The conditional nature of the ti...

BACKGROUND Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the h...

TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: disordered breathing (SDB) is common in pregnancy. A relationship has been described late pregnancy between SDB and abnormal glucose metabolism, gestational diabetes mellitus (GDM). However, it remains unclear whether this starts early or develops following exposure to pregnancy.The goal of the current study examine association its s...

Homa is a new transport protocol for datacenter networks. It provides exceptionally low latency, especially for workloads with a high volume of very short messages, and it also supports large messages and high network utilization. Homa uses in-network priority queues to ensure low latency for short messages; priority allocation is managed dynamically by each receiver and integrated with a recei...

OBJECTIVES The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. METHODS In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormon...