PURPOSE To investigate the effect of a transient complete ischemia on the function of cat retina and to determine whether nerve growth factor (NGF), which was previously shown to enhance retinal ganglion cell (RGC) survival after optic nerve section in the adult rat, can promote recovery of retinal neurons after the ischemic insult. METHODS Function of distal and proximal retina was assessed ...

PURPOSE To determine normative values for pattern-reversal electroretinogram (PERG) in healthy adult volunteers according to the standard protocol recommended by the International Society for Clinical Electrophysiology of Vision-ISCEV. METHODS Participants were 30 healthy volunteers (15 males) with ages from 18 to 61 years (mean= 30.8 +/- 8.7 yrs.; median= 29.5 yrs). Inclusion criteria were: ...

OBJECTIVE To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP) responses in patients with ocular hypertension or open-angle glaucoma (OAG). DESIGN Retrospective, cross-sectional, case-control study. PARTICIPANTS Eighty normal control subjects (mean age, 51.77+/-6.04 years; 80 eyes), 68 ocular hypertension patients (mean age, 51.58+/...

PURPOSE To evaluate the effects of photodynamic therapy (PDT) on macular function in myopic subfoveal choroidal neovascularization (CNV). METHODS Fourteen eyes of 14 patients (mean age, 48.1 +/- 13.3 years) with myopic CNV (myopia ranging from -6.50 to -20 D) were enrolled. In each eye, at baseline and at 15 and 90 days after PDT with verteporfin, logMAR visual acuity (logarithm of the minimu...

Injury to retinal ganglion cell (RGC) axons leads to selective loss of RGCs and vision. Previous studies have shown that exogenous neurotrophic factors promote RGC survival. We investigated the neuroprotective effects of oncostatin M (OSM), a member of the IL-6 family of cytokines, on pattern electroretinogram (PERG) and RGC survival after optic nerve crush (ON-crush) in the mouse. BALB/C mice ...

Forskolin, magnesium, homotaurin, L-carnosin, vitamins B1, B2, B6 and folic acid are the main ingredients of a food supplement commercially available. This drug contributes to a small reduction of IOP in glaucomatous patients who are poorly responsive to multitherapy treatment. The aim of this study is to evaluate a possible change of visual field and pattern-electroretinogram (PERG) parameters...

2 respuestas: un componente positivo, P1 (P50 luminanciaas enfermedades neurodegenerativas son muy heterogéneas n cuanto a sus síntomas y hallazgos anatomopatológicos. Se esconocen las causas que provocan la pérdida neuronal en stas patologías. De hecho, los procesos en los que se prouce una pérdida de neuronas por una causa conocida (por jemplo, los episodios de desmielinización o los trastorn...