BRCA1 plays a critical role in homology-directed repair (HDR) of DNA double strand breaks, and the repair defect of BRCA1-mutant cancer cells is being targeted with platinum drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. We have employed relatively simple and sensitive assays to determine the function of BRCA1 variants or mutants in two HDR mechanisms, homologous recombination (HR) a...

High Dynamic Range (HDR) video offers the possibility, for the first time, of capturing, storing, manipulating, and displaying dynamic real-world lighting. This gives a step change in viewing experience, for example the ability to clearly see the football when it is kicked from the shadow of the stadium into sunshine. An HDR video camera now exists which is capable of capturing 20 f-stops at fu...

While tone mapping operation of high dynamic range (HDR) images for realistic display is commonly researched, scientific visualization for analysing scene luminance within HDR image has much less attention from researches. This paper has presented and implemented an approach for the reproduction and visualization of the colour information in HDR images. We attempt several simple colour visualiz...

High dose rate (HDR) endobronchial brachytherapy is a palliative treatment for symptomatic airway obstruction by malignant tumours. We report a novel use of HDR brachytherapy for treating nonmalignant bronchial obstruction. The patient had a metal stent placed in a reconstructed airway after a bronchial tear to ensure patency. Granulation tissue formation in and around the stent caused symptoma...

High dose rate (HDR) endobronchial brachytherapy is a palliative treatment for symptomatic airway obstruction by malignant tumours. We report a novel use of HDR brachytherapy for treating non-malignant bronchial obstruction. The patient had a metal stent placed in a reconstructed airway after a bronchial tear to ensure patency. Granulation tissue formation in and around the stent caused symptom...

Although HDR content processing, coding and quality assessment have been largely addressed in the last few years, little to no work has been concentrating on how to assess quality in HDR for 360◦ or omnidirectional content. This paper is an attempt to answer to various questions in this direction. As a minimum, a new data set for 360◦ HDR content is proposed and a new methodology is designed to...

To the Editor: Genome editing via programmable endonucleases enables us to generate site-specific double-strand breaks at virtually any position in a target genome.1–3 Exploiting cellular repair mechanisms, this can be used for targeted gene disruption via nonhomologous end joining (NHEJ) or for the precise manipulation of a target sequence through homology-directed repair (HDR) in the presence...