The two, nearly identical, isoforms of human progesterone receptors (PR), PR-B and -A, share activation functions (AF) 1 and 2, yet they possess markedly different transcriptional profiles, with PR-B being much stronger transactivators. Their differences map to a unique AF3 in the B-upstream segment (BUS), at the far N terminus of PR-B, which is missing in PR-A. Combined mutation of two LXXLL m...

AIMS Pulmonary regurgitation (PR) is an important determinant of outcome after tetralogy of Fallot (TOF) repair. The physiologic impact of PR on the right ventricle remains incompletely understood. We hypothesized that a volumetric expression of PR would be a better measure of ventricular preload and a more accurate reflection of degree of insufficiency. METHODS AND RESULTS Patients (n = 64) ...

  Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on...

ABSTRACT- Over the past 50 years, oil mulching has been a common technique for sand dune stabilization in the southwest of Iran (Khuzestan province). However, concerns over the release of heavy metals from oil mulching have led to the search for alternative mulches that are capable of stabilizing sand dunes without environmental hazards. This study investigates the feasibility of using sugarcan...

Pityriasis rosea is a short-lived rash that commences initially as a large so-called ‘herald’ patch followed by a rapidly evolving eruption on the trunk and extremities. Characteristic pattern of lesions follow the lines of cleavage in a ‘christmas tree’ distribution. PR is most frequently seen between first and third decade but a range of 3 month to 83 years were reported. The incidence doesn’...

the aim of this study was to investigate the effect of three types of resistance training program on girls' physical fitness. 30 girls were divided into 3 groups: plyometric training with vascular occlusion (plo), plyometric training without vascular occlusion (pl) and power-resistance training (pr). training programs were conducted for six weeks. physical fitness tests were conducted befo...

background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...

The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor that mediates progesterone action in target tissues. Two PR proteins, PR-A (M(r) 81,000-83,000) and PR-B (M(r) 116,000-120,000), have been described and different physiological activities ascribed to each on the basis of in vitro studies, suggesting that their ratio of expression may control progesterone res...

Dimerization of HIV-1 protease (PR) subunits is an essential process for PR's acquisition of proteolytic activity, which plays a critical role in the maturation of HIV-1. Recombinant wild-type PR (PR(WT)) proved to dimerize, as examined with electrospray ionization mass spectrometry; however, two active site interface PR mutants (PR(T26A) and PR(R87K)) remained monomeric. On the other hand, two...